Memory and learning – using mouse to model neurobiological and behavioural aspects of Down syndrome and assess pharmacotherapeutics

This paper by Katheleen Gardiner reviews the challenges inherent in using mouse models in Down syndrome research and then describes the successful molecular/genetic interventions that are cause for cautious optimism. The paper also predicts critical molecular abnormalities that can be tested for relevance to learning and memory and that are potential targets of existing pharmacotherapeutics. Read full article at: http://www.down-syndrome.org/reviews/2096/